The following are extracted from published clinical studies, in-house studies, and/or case studies and are for
reference purposes only. This does not imply that the product from Lifestream Group Pte Ltd is claimed to
replicate the same results produced in the studies. This information is not a substitute for professional
medical advice, diagnosis, or treatment. If you have any questions about a medical condition, please consult
your physician or other qualified healthcare providers. Any statements or claims made have not been
evaluated by the relevant regulatory bodies and are not intended to diagnose, treat, cure, or prevent any
disease. By using the Site, you agree that you have read and acknowledge the above and the Terms of Use for this Site.
High triglycerides may contribute to hardening and thickening of the artery walls, increasing the risk of
cardiovascular conditions, such as heart attack or stroke. Research suggests that omega-3 fatty acids
can help reduce blood triglyceride levels, thereby supporting healthy cardiovascular system.
Study 1: In a clinical trial, diabetic individuals were orally administered fish oil supplement
equivalent to 35 mg omega-3 per kg body weight for 3 months.
Fish oil supplementation results in a significant reduction of
plasma triglyceride level (p < 0.05), suggesting the beneficial effects of
omega-3 intake on blood triglyceride levels (Diabetologia 40: 45–52 (1997)).
Study 2: In this clinical trial, hyperlipidemic subjects were orally administered fish oil that
contained approximately 17% EPA, 12% DHA daily for 12 weeks. Compared to control,
fish oil administration resulted in a significant reduction of triglycerides, total cholesterol and increase of
HDL cholesterol, suggesting the beneficial effects of omega-3 supplementation in hyperlipidemic subjects.
Med Sci Sports Exerc. 21(5): 498-505 (1989)
lifestyle changes, such as exercise, reduced salt intake and limiting alcohol also help reduce high blood pressure.
In this clinical study, peritoneal dialysis patients were orally administered either 3g of omega-3 or placebo per day
mean systolic blood pressure decreased in the omega-3 group but increased in the placebo group.
Cardiovascular diseases are the leading cause of death globally. Omega-3 fatty acids is beneficial to cardiovascular health
by reducing the risk of formation of fatty deposits in the arteries and inflammation by inducing the expression of
adipokines, such as apelin, which helps protect against incidence and progression of cardiovascular diseases.
In this clinical trial, patients with cardiovascular diseases were orally administered 4g of omega-3 fatty acids
(720 mg EPA and 480 mg DHA) or placebo for 8 weeks. Compared to placebo, omega-3 intake significantly
increased serum apelin levels (p= 0.018), decreased the levels of LDL (bad) cholesterol and serum hs-CRP
(inflammatory marker) concentrations (p = 0.007). Compared to baseline, concentrations of VLDL
triglycerides and hs-CRP and significantly reduced in omega-3 fatty acids group (p < 0.05). These findings
suggest the beneficial effects of omega-3 fatty acids to cardiovascular system.
Alzheimer’s disease may begin 20 years or more before the onset of the symptoms, including changes in memory, thinking or behaviour.
Hence, preventive approach for Alzheimer’s disease is of the utmost important. Omega-3 fatty acids are extremely important
in brain function and development. Ingestion of omega-3 fatty acids help improve cognitive functions, such as memory,
learning, as well as blood flow in the brain.
In this clinical trial, cognitively healthy elderly older adults aged 50 to 75 years were orally administered 2.2 g omega-3 fatty acids or
placebo daily for 26 weeks. Omega-3 index and memory performance in the object-location memory (OLM)- task were determined before and after intervention. Compared to the placebo group, omega-3 supplementation significantly increased omega-3 index. Moreover,
recall of object locations (OLM-task) was significantly better after omega-3 supplementation. These findings suggest
the potential application of omega-3 fatty acids in maintaining cognitive functions in older adults (JAlzheimers Dis. 51(3):713-725 (2016)).
Depression is a common mental disorder affecting approximately 5% of adults globally. This disorder is associated with
continuous depressed mood or sadness and having no motivation or interest in activities for long periods of time.
Among the three types of omega-3 (ALA, EPA and DHA), EPA appears to be most effective in managing depression.
In this study, 4150 postmenopausal women were divided into 5 groups according to their dietary omega-3 fatty acid intake,
which are 0.3, 0.6, 0.9, 1.4 and 2.7g/day. The group with the highest dietary omega-3 fatty acid intake shows a
significantly lower prevalence of depression that the group with the lowest intake. Besides, the dietary omega-3 intake is inversely proportional
to depression in a dose-dependent manner. These suggests the beneficial effects of omega-3 in protecting against and mitigating depression.
i) Help relieve dry eyes
Dry eye happens when the eyes do not produce sufficient tears to provide lubrication for the eyes. This condition commonly
occurs in certain situations, such as staring at phone or computer screen for too long or in an air-conditioned room.
Among the common symptoms of dry eyes are burning sensation in the eyes, eye redness, watery or teary eyes.
Omega-3 fatty acids appear to improve the function of meibomian glands, which secrete oil to coat the surface of the
eyes, as well as reduce evaporation of water component of tears, thereby easing dry eye symptoms.
In this clinical study, patients aged 45 to 90 years with dry eye symptoms were orally administered omega-3 fatty acids
(360 mg EPA and 240 DHA) or placebo (medium-chain triglyceride oil) daily for 30 days and tear break-up time (TBUT),
Schirmer’s score, and Ocular Surface Disease Index (OSDI) were determined at baseline and at day 30. TBUT is a clinical test
used to assess evaporative dry eye disease. Schirmer test assess if the eyes secrete sufficient tears to keep them moist,
while OSDI is a questionnaire to assess symptoms relevant to dry eye disease and their effect on vision. Compared to baseline,
improvement in TBUT, Schirmer’s scores and OSDI were significantly better in the omega-3 group than in the placebo group.
These findings suggest that consumption of omega-3 fatty acids help reduce rate of tear evaporation,
increase tear secretion and improve dry eye symptoms.
ii) Support healthy eye pressure
Eye pressure, which is also known as intraocular pressure (IOP) is a measurement of the fluid pressure inside the eyes.
Normal ocular pressure is considered between 10 to 20 mm Hg. High IOP or ocular hypertension can add stress on the
parts inside the eyes, which can damage the optic nerve. The untreated high eye pressure can
cause glaucoma and permanent vision loss. Studies show that lowering ocular pressure could help protect against vision loss
from glaucoma. Omega-3 fatty acids help decrease ocular pressure, improve ocular blood flow and exhibit optic
neuroprotective function, which could be beneficial to those with high risk of glaucoma.
In this study, adults with IOP <21 mm Hg and without a current or prior glaucoma diagnosis were orally administered omega-3
(~1000 mg/day EPA + ~500 mg/day DHA) or placebo (olive oil, 1500 mg/day) daily for 90 days and their IOP was
quantified at baseline and after 90 days. Compared to baseline, the IOP was reduce in the omag-3 group and placebo showed
a slight increase in IOP at day 90. These findings suggest that omega-3 supplementation
for 3 months helps lower IOP in normotensive subjects.
The following are extracted from
published clinical studies, in-house
studies, and/or case studies and are for
reference purposes only. This does not
imply that the product from Lifestream
Group Pte Ltd is claimed to replicate the
same results produced in the studies.
This information is not a substitute for
professional medical advice, diagnosis, or
treatment. If you have any questions
about a medical condition, please consult
your physician or other qualified
healthcare providers. Any statements or
claims made have not been evaluated by
the relevant regulatory bodies and are not
intended to diagnose, treat, cure, or
prevent any disease. By using the Site,
you agree that you have read and
acknowledge the above and the Terms of
Use for this Site.
High triglycerides may contribute to hardening and thickening of the artery walls, increasing the risk of cardiovascular conditions, such as heart attack or stroke. Research suggests that omega-3 fatty acids can help reduce blood triglyceride levels, thereby supporting healthy cardiovascular system.
Study 1: In a clinical trial, diabetic individuals were orally administered fish oil supplement equivalent to 35 mg omega-3 per kg body weight for 3 months. Fish oil supplementation results in a significant reduction of plasma triglyceride level (p < 0.05), suggesting the beneficial effects of omega-3 intake on blood triglyceride levels (Diabetologia 40: 45–52 (1997)).
Study 2: In this clinical trial, hyperlipidemic subjects were orally administered fish oil that contained approximately 17% EPA, 12% DHA daily for 12 weeks. Compared to control, fish oil administration resulted in a significant reduction of triglycerides, total cholesterol and increase of HDL cholesterol, suggesting the beneficial effects of omega-3 supplementation in hyperlipidemic subjects.
Med Sci Sports Exerc. 21(5): 498-505 (1989)
In this clinical study, peritoneal dialysis patients were orally administered either 3g of omega-3 or placebo per day for 8 weeks and their blood pressure was monitored at baseline and at the end of 8 weeks. At the end of the study, the mean systolic blood pressure decreased in the omega-3 group but increased in the placebo group. Besides, mean diastolic blood pressure decreased more in the omega-3 group, compared to the placebo group. These findings indicate that omega-3 fatty acids help reduce blood pressure significantly.
Cardiovascular diseases are the leading cause of death globally. Omega-3 fatty acids is beneficial to cardiovascular health by reducing the risk of formation of fatty deposits in the arteries and inflammation by inducing the expression of adipokines, such as apelin, which helps protect against incidence and progression of cardiovascular diseases.
In this clinical trial, patients with cardiovascular diseases were orally administered 4g of omega-3 fatty acids (720 mg EPA and 480 mg DHA) or placebo for 8 weeks. Compared to placebo, omega-3 intake significantly increased serum apelin levels (p= 0.018), decreased the levels of LDL (bad) cholesterol and serum hs-CRP (inflammatory marker) concentrations (p = 0.007). Compared to baseline, concentrations of VLDL triglycerides and hs-CRP and significantly reduced in omega-3 fatty acids group (p < 0.05). These findings suggest the beneficial effects of omega-3 fatty acids to cardiovascular system.
Alzheimer’s disease may begin 20 years or more before the onset of the symptoms, including changes in memory, thinking or behaviour. Hence, preventive approach for Alzheimer’s disease is of the utmost important. Omega-3 fatty acids are extremely important in brain function and development. Ingestion of omega-3 fatty acids help improve cognitive functions, such as memory, learning, as well as blood flow in the brain.
In this clinical trial, cognitively healthy elderly older adults aged 50 to 75 years were orally administered 2.2 g omega-3 fatty acids or placebo daily for 26 weeks. Omega-3 index and memory performance in the object-location memory (OLM)- task were determined before and after intervention. Compared to the placebo group, omega-3 supplementation significantly increased omega-3 index. Moreover, recall of object locations (OLM-task) was significantly better after omega-3 supplementation. These findings suggest the potential application of omega-3 fatty acids in maintaining cognitive functions in older adults (JAlzheimers Dis. 51(3):713-725 (2016)).
Depression is a common mental disorder affecting approximately 5% of adults globally. This disorder is associated with continuous depressed mood or sadness and having no motivation or interest in activities for long periods of time. Among the three types of omega-3 (ALA, EPA and DHA), EPA appears to be most effective in managing depression.
In this study, 4150 postmenopausal women were divided into 5 groups according to their dietary omega-3 fatty acid intake, which are 0.3, 0.6, 0.9, 1.4 and 2.7g/day. The group with the highest dietary omega-3 fatty acid intake shows a significantly lower prevalence of depression that the group with the lowest intake. Besides, the dietary omega-3 intake is inversely proportional to depression in a dose-dependent manner. These suggests the beneficial effects of omega-3 in protecting against and mitigating depression.
i) Help relieve dry eyes
Dry eye happens when the eyes do not produce sufficient tears to provide lubrication for the eyes. This condition commonly occurs in certain situations, such as staring at phone or computer screen for too long or in an air-conditioned room. Among the common symptoms of dry eyes are burning sensation in the eyes, eye redness, watery or teary eyes. Omega-3 fatty acids appear to improve the function of meibomian glands, which secrete oil to coat the surface of the eyes, as well as reduce evaporation of water component of tears, thereby easing dry eye symptoms.
In this clinical study, patients aged 45 to 90 years with dry eye symptoms were orally administered omega-3 fatty acids (360 mg EPA and 240 DHA) or placebo (medium-chain triglyceride oil) daily for 30 days and tear break-up time (TBUT), Schirmer’s score, and Ocular Surface Disease Index (OSDI) were determined at baseline and at day 30. TBUT is a clinical test used to assess evaporative dry eye disease. Schirmer test assess if the eyes secrete sufficient tears to keep them moist, while OSDI is a questionnaire to assess symptoms relevant to dry eye disease and their effect on vision. Compared to baseline, improvement in TBUT, Schirmer’s scores and OSDI were significantly better in the omega-3 group than in the placebo group. These findings suggest that consumption of omega-3 fatty acids help reduce rate of tear evaporation, increase tear secretion and improve dry eye symptoms.
ii) Support healthy eye pressure
Eye pressure, which is also known as intraocular pressure (IOP) is a measurement of the fluid pressure inside the eyes. Normal ocular pressure is considered between 10 to 20 mm Hg. High IOP or ocular hypertension can add stress on the parts inside the eyes, which can damage the optic nerve. The untreated high eye pressure can cause glaucoma and permanent vision loss. Studies show that lowering ocular pressure could help protect against vision loss from glaucoma. Omega-3 fatty acids help decrease ocular pressure, improve ocular blood flow and exhibit optic neuroprotective function, which could be beneficial to those with high risk of glaucoma.
In this study, adults with IOP <21 mm Hg and without a current or prior glaucoma diagnosis were orally administered omega-3 (~1000 mg/day EPA + ~500 mg/day DHA) or placebo (olive oil, 1500 mg/day) daily for 90 days and their IOP was quantified at baseline and after 90 days. Compared to baseline, the IOP was reduce in the omag-3 group and placebo showed a slight increase in IOP at day 90. These findings suggest that omega-3 supplementation for 3 months helps lower IOP in normotensive subjects.